Tracer development: WP01 and WP02

The main objective is to develop and evaluate novel imaging probes, which are markers for the function of the multidrug transporters that form part of the BBB.

Using a multidisciplinary approach integrating radiochemistry, molecular and cellular biology, physics, physiology, pharmacology, pathology and genetics, we will synthesize novel imaging probes for the visualisation of cerebral multidrug transporters (WP01) and carry out proof-of-principle studies of newly developed radiotracers in animal models of drug resistance (WP02).