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University of Liverpool
Department of Pharmacology
The Sherrington Buildings, Ashton Street
L69 3GE Liverpool
United Kingdom
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Prof. Dr. Munir Pirmohamed Phone: +44-(0)151-794 5549 Fax: +44-(0) 151-794 5540  Contact |
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Dr. Ana Alfirevic Lecturer Phone: +44-(0)151-794 5551 Fax: +44-(0) 151-794 5540 Contact |
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Dr. David Dickens Postdoctoral Researcher Phone: +44-(0)151 794 5919 Fax: +44-(0)0151 794 5656 Contact |
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Dr. Andrew Owen Lecturer Phone: +44-(0)151-794 8211 Fax: +44-(0) 151-794 5540 Contact |
The University of Liverpool is part of the Russell group of universities in the UK with an annual research income of approximately £100 million. Pharmacology and Therapeutics is one of the top-rated pharmacology departments in the UK, and is well recognised for its studies in drug disposition and how this affects drug response. The Department has a seamless link between basic and clinical scientists, and this allows its research to span from in vitro studies right through to implementation into clinical practice. This has been the premise of its research in the area of epilepsy, which has focused on three main areas: (a) idiosyncratic reactions of anti-epileptic drugs (AEDs), (b) pharmacogenetics of AEDs and (c) mechanisms of drug resistance in epilepsy. In addition to the above, we have also undertaken studies with drugs used in HIV, CML (conditions that can affect the CNS) and Alzheimer’s disease. With respect to the general area of research on transporters, we have extensive experience of in vitro methodologies to assess transport of drugs using primary and transfected cells (with different transporters – all available in the Dept), the effects of inhibitors and siRNA technology on transport, induction of transporters, characterisation of the genetic architecture of transporter genes and investigation of the relationship between genotype and clinical response, and in vitro phenotype. In addition, we have access to radiolabelled compounds, laboratory facilities to handle these compounds, and where radiolabelled compounds are unavailable, extensive bioanalytical facilities to determine drug concentrations.
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