EURIPIDES Dissemination Activities

Publications and other dissemination activities have to include the following statement:

"The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 201380."

• Publications
  
• Poster
  
• Radio
  

Publications

• New radiotracer which emerged from the EURIPIDES radiotracer development program:
  Synthesis and Small-Animal Positron Emission Tomography Evaluation of [(11)C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood-Brain Barrier. Do¨rner B, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Mairinger S, Lo¨scher W, Mu¨ller M, Langer O, Erker T. J Med Chem. 2009 Aug 27. [Epub ahead of print]
   pubmed link

• Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats.
  Luurtsema G, Schuit RC, Klok RP, Verbeek J, Leysen JE, Lammertsma AA. Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nuclear Medicine Biology. Vol 36, issue 6; Aug 2009
   pubmed link

• Assessing functional activity of P-gp at the rat blood-brain barrier with PET

  Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Müller M, Löscher W, Langer O. Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med. 2008 Aug;49(8):1328-35. Epub 2008 Jul 16.
   pubmed link

• Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients
  Aiman Abrahim, Gert Luurtsema, Martin Bauer, Rudolf Karch, Ekaterina Pataraia, Christian Joukhadar, Kurt Kletter, Adriaan A. Lammertsma, Christoph Baumgartner, Markus Müller, Oliver Langer. Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients. Eur J Nucl Med Mol I 35(1):116-123 (2008)
   pubmed link

• Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus
  Bankstahl JP, Löscher W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res. 2008 Aug 28.
   pubmed link

• Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases?
  Hoffmann K, Czapp M, Löscher W. Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases? Epilepsy Res. 2008 Jun 4.
   pubmed link

• Het EURIPIDES project. Epilepsie, periodiek voor professionals
  R.A. Voskuyl, Het EURIPIDES project. Epilepsie, periodiek voor professionals,  6 (2); 2008, 5. (In Dutch; Bulletin of the Dutch League against Epilepsy)
  

 

• “P-glycoprotein modulation at the rat BBB studied with 11C-Verapamil PET” won the “Drug Discovery Image of the Year” award at the annual Siemens Preclinical Imaging competition, Nice, France
  
   download presentation
  
   press release

 

Poster

 

• On the Role of P-Glycoprotein Function in the Blood-Brain Barrier in Pharmacoresistance: A PET study in Epileptic Rats.
  Stina Syvänen, Gert Luurtsema, Carla F.M. Molthoff, Albert D. Windhorst, Marc C. Huisman, Adriaan A. Lammertsma,
  Rob A. Voskuyl and Elizabeth C.M. de Lange. On the Role of P-Glycoprotein Function in the Blood-Brain Barrier in Pharmacoresistance: A PET study in Epileptic Rats. Conference, AES Annual Meeting 2009, Boston.
   download poster
  
  
• Synthesis and biological evaluation of D617: A metabolite of verapamil.
  poster presented on the 18th international symposium on radiopharmaceutical sciences 12 -17 july 2009 in Edmonton (poster 238)
  Authors: J.Verbeek, A.D. Windhorst, R.C. Schuit, J. Eriksson, S. Syvanen, A.A. Lammertsma and G. L. Luurtsema. VUmc and LACDR
   download poster
  
  
• PGP action in temporal lobe epilepsy explored with [18F]MPPF: Intermediate results after blockade of PGP with cyclosporine A.
  A. Hammers, S. Bouvard, N. Costes, E. Pereira de Souza Neto, A. Lothe, S. Keihaninejad, D. Le Bars, A. Didelot, F. Mauguière, M.J. Koepp, E. Hirsch, P. Ryvelin. PGP action in temporal lobe epilepsy explored with [18F]MPPF: Intermediate results after blockade of PGP with cyclosporine A. 28th International Epilepsy Congress, Budapest, Hungary.
   download poster
  
  
• P-glycoprotein function in the blood-brain barrier of epileptic rats.
  S.M. Syvänen, G. Luurtsema, C.F.M. Molthoff, A.D. Windhorst, M.C. Huisman, A.A. Lammertsma, R.A. Voskuyl, E.C. de Lange. P-glycoprotein function in the blood-brain barrier of epileptic rats. Conference: Brain'09. 01.07.2009, Chicago
   download poster

• Uptake and Binding of the 5-HT1A Antagonist [18F]MPPF in Brain of rats; Effects of the novel P-glycoprotein Inhibitor Tariquidar.
  Christian la Fougère, Hero Bartmann, Guido Böning, Sebastian Nowak, Theresa Just, Björn Wängler, Axel  Rominger, Franz-Josef Gildehaus, Heidrun Potschka, Paul Cumming, Peter Bartenstein: Uptake and Binding of the 5-HT1A Antagonist [18F]MPPF in Brain of rats; Effects of the novel P-glycoprotein Inhibitor Tariquidar. Annual Meeting of the American Society of Nuclear Medicine, 13. June 2009, Toronto, Canada.
   download poster
  
  
• RRT and Advance scanner comparison using a steady-state scan approach.
  Svarer C, Marner L, Madsen K, Keller SH1, Haahr M, Sibomana M1, and Knudsen GM. RRT and Advance scanner comparison using a steady-state scan approach. Society of Nuclear Medicine 2009 Annual Meeting in Toronto, 13.06.2009
   download poster
  
  
• Drugs for brain diseases. Do the get in?
  S.M. Syvänen, R.A. Voskuyl, E.C. de Lange. Drugs for brain diseases. Do the get in? 10.04.2009, Leiden
   download poster

• Impact of the P-glycoprotein inhibitor tariquidar on brain uptake of the serotonin 5-HT1a antagoist [18F]-MPPF in rats.
  H. Bartmann, C. la Fougere, G. Böning, S. Nowak, Th. Just, E. Wagner, P. Winter, A. Rominger, S. Förster, F.J. Gildehaus, P. Rosa-Neto, L. Minuzzi, P. Bartenstein, H. Potschka, P. Cumming. Impact of the P-glycoprotein inhibitor tariquidar on brain uptake of the serotonin 5-HT1a antagoist [18F]-MPPF in rats. Meeting of the German Society of Pharmacology and Toxicology, 10. March 2009, Mainz, Germany.
   download poster
  
  
  
• Pharmacoresistance in Epilepsy Assessment of altered P-gp expression with PET.
  E.C.M. de Lange, A.A. Lammertsma and R.A. Voskuyl , Pharmacoresistance in Epilepsy Assessment of altered P-gp expression with PET. Symposium on Translational Research in Neuroscience, 23.04.2008, Leiden
   download poster

• Regional variations in age-dependence of P-gp mediated transport across the blood-brain barrier measured using (R )-[11C]verapamil and PET,
  new findings by the VUmc-group from Amsterdam presented at the International Conference on Alzheimers Disease in Chicago, USA on 30-7-2008 by Danielle M.E. van Assema
   download poster

 

• Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier.
  Jens P. Bankstahl, Claudia Kuntner, Aiman Abrahim, Rudolf Karch, Wolfgang Löscher, Oliver Langer. Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-[11C]verapamil and positron emission tomography. 8th European Congress on Epilepsy; 21.09.2008, Berlin, Germany
   download poster
  
  
• Increased brain uptake of (R)-[11C]-verapamil in rats following administration of the P-glycoprotein inhibitors  elacridar and tariquidar quantified with small animal positron emission tomography
  poster awarded at the "6. Gemeinsamen Jahrestagung der Deutschen, Österreichischen und Schweizer Sektionen der Internationalen Liga gegen Epilepsie vom 20.- 23. Mai 2009 in Rostock"
  Authors: J. P. Bankstahl, C. Kuntner, M. Bankstahl, O. Langer, W. Löscher.
   download poster

 

Radio

• BBC Radio 4 Programme, "Material World", 17th April 2008 "Blood Brain Barrier"
  Quentin Cooper reports on developments across the sciences. Each week scientists describe their work, conveying the excitement they feel for their research projects.
   BBC website